Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study

Mihoko Nakamura, Tsutomu Takahashi, Yoichiro Takayanagi, Daiki Sasabayashi, Naoyuki Katagiri, Atsushi Sakuma, Chika Obara, Shinsuke Koike, Hidenori Yamasue, Atsushi Furuichi, Mikio Kido, Yumiko Nishikawa, Kyo Noguchi, Kazunori Matsumoto, Masafumi Mizuno, Kiyoto Kasai, Michio Suzuki

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the ‘H-shaped’ orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psychosis also exhibit these gross morphologic anomalies is not well documented. This multicenter MRI study from four scanning sites in Japan investigated the distribution of the number of intermediate and posterior orbital sulci, as well as the OFC sulcogyral pattern, in 125 individuals with an at-risk mental state (ARMS) [of whom 22 later developed psychosis (ARMS-P) and 89 did not (ARMS-NP)] and 110 healthy controls. The ARMS group as a whole had a significantly lower number of intermediate and posterior orbital sulci compared with the controls, which was associated with prodromal symptomatology. However, there was no group difference in OFC pattern distribution. The ARMS-P and -NP groups did not differ in OFC surface morphology. These results suggest that gross morphology of the OFC in high-risk subjects may at least partly reflect neurodevelopmental pathology related to vulnerability to psychosis.

Original languageEnglish
Pages (from-to)397-406
Number of pages10
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number4
Publication statusPublished - 2019 Jun 1


  • High-risk
  • Magnetic resonance imaging
  • Multicenter
  • Orbitofrontal cortex
  • Psychosis
  • Sulcogyral pattern

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)


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