The ability of surface-assisted laser desorption/ionization mass spectroscopy (SALDI-MS) of low-molecular-weight compounds using six types of commercially available TiO2 nanoparticles (NPs) was examined. In all cases, TiO2 NPs gave strong Na+-adduct sample ion peaks. Some chemicals, which rarely show proton-adduct sample ion peaks by MALDI-MS, such as aspirin and barbital, could be easily detected by using TiO2 NPs. The key factors determining the SALDI ability of TiO2 NPs are their purity, ratio of rutile, and particle size.
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