Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) of low-molecular-weight medicines and toxic materials using commercial TiO2 nanoparticles

Tetsu Yonezawa, Takashi Asano, Masaki Matsubara

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The ability of surface-assisted laser desorption/ionization mass spectroscopy (SALDI-MS) of low-molecular-weight compounds using six types of commercially available TiO2 nanoparticles (NPs) was examined. In all cases, TiO2 NPs gave strong Na+-adduct sample ion peaks. Some chemicals, which rarely show proton-adduct sample ion peaks by MALDI-MS, such as aspirin and barbital, could be easily detected by using TiO2 NPs. The key factors determining the SALDI ability of TiO2 NPs are their purity, ratio of rutile, and particle size.

Original languageEnglish
Pages (from-to)346-353
Number of pages8
JournalBulletin of the Chemical Society of Japan
Volume89
Issue number3
DOIs
Publication statusPublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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