Supramolecular Enzyme Mimics

Y. Okamoto, T. R. Ward

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)


Artificial metalloenzymes result from the incorporation of an organometallic moiety within a macromolecule. In this article, we review the field of artificial metalloenzymes. These are classified according to the host that accommodates the organometallic cofactor: cyclodextrins ("Cyclodextrin-Based Artificial Enzymes" section), ligands bearing a substrate recognition motif ("Artificial Enzymes With Ligands Bearing Substrate Recognition Motifs" section), supramolecular cages ("Cage Molecules as Artificial Enzymes" section), nucleic acids ("DNA-Based Artificial Metalloenzymes" section), and proteins ("Protein-Based Artificial Enzymes" section). Both dative and supramolecular anchoring strategies are reviewed.

Original languageEnglish
Title of host publicationBioinspired and Biomimetic Supramolecular Chemistry
PublisherElsevier Inc.
Number of pages52
ISBN (Electronic)9780128031988
ISBN (Print)9780128031995
Publication statusPublished - 2017 Jun 22
Externally publishedYes


  • Artificial metalloenzyme
  • Cage molecule
  • Catalysis
  • Cyclodextrin
  • Dative anchoring
  • Double-stranded DNA
  • G-quadruplex
  • Hydrogen bonding
  • Molecular recognition
  • Protein
  • Reaction compartment
  • Supramolecular anchoring

ASJC Scopus subject areas

  • Chemistry(all)


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