Supramolecular Enzyme Mimics

Y. Okamoto, T. R. Ward

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Artificial metalloenzymes result from the incorporation of an organometallic moiety within a macromolecule. In this article, we review the field of artificial metalloenzymes. These are classified according to the host that accommodates the organometallic cofactor: cyclodextrins ("Cyclodextrin-Based Artificial Enzymes" section), ligands bearing a substrate recognition motif ("Artificial Enzymes With Ligands Bearing Substrate Recognition Motifs" section), supramolecular cages ("Cage Molecules as Artificial Enzymes" section), nucleic acids ("DNA-Based Artificial Metalloenzymes" section), and proteins ("Protein-Based Artificial Enzymes" section). Both dative and supramolecular anchoring strategies are reviewed.

Original languageEnglish
Title of host publicationBioinspired and Biomimetic Supramolecular Chemistry
PublisherElsevier Inc.
Pages459-510
Number of pages52
Volume4
ISBN (Electronic)9780128031988
ISBN (Print)9780128031995
DOIs
Publication statusPublished - 2017 Jun 22
Externally publishedYes

Keywords

  • Artificial metalloenzyme
  • Cage molecule
  • Catalysis
  • Cyclodextrin
  • Dative anchoring
  • Double-stranded DNA
  • G-quadruplex
  • Hydrogen bonding
  • Molecular recognition
  • Protein
  • Reaction compartment
  • Supramolecular anchoring

ASJC Scopus subject areas

  • Chemistry(all)

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