Abstract
Artificial metalloenzymes result from the incorporation of an organometallic moiety within a macromolecule. In this article, we review the field of artificial metalloenzymes. These are classified according to the host that accommodates the organometallic cofactor: cyclodextrins ("Cyclodextrin-Based Artificial Enzymes" section), ligands bearing a substrate recognition motif ("Artificial Enzymes With Ligands Bearing Substrate Recognition Motifs" section), supramolecular cages ("Cage Molecules as Artificial Enzymes" section), nucleic acids ("DNA-Based Artificial Metalloenzymes" section), and proteins ("Protein-Based Artificial Enzymes" section). Both dative and supramolecular anchoring strategies are reviewed.
Original language | English |
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Title of host publication | Bioinspired and Biomimetic Supramolecular Chemistry |
Publisher | Elsevier Inc. |
Pages | 459-510 |
Number of pages | 52 |
Volume | 4 |
ISBN (Electronic) | 9780128031988 |
ISBN (Print) | 9780128031995 |
DOIs | |
Publication status | Published - 2017 Jun 22 |
Externally published | Yes |
Keywords
- Artificial metalloenzyme
- Cage molecule
- Catalysis
- Cyclodextrin
- Dative anchoring
- Double-stranded DNA
- G-quadruplex
- Hydrogen bonding
- Molecular recognition
- Protein
- Reaction compartment
- Supramolecular anchoring
ASJC Scopus subject areas
- Chemistry(all)