Supramolecular 1-D polymerization of DNA origami through a dynamic process at the 2-dimensionally confined air-water interface

Yusuke Yonamine, Keitel Cervantes-Salguero, Kosuke Minami, Ibuki Kawamata, Waka Nakanishi, Jonathan P. Hill, Satoshi Murata, Katsuhiko Ariga

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

In this study, a Langmuir-Blodgett (LB) system has been utilized for the regulation of polymerization of a DNA origami structure at the air-water interface as a two-dimensionally confined medium, which enables dynamic condensation of DNA origami units through variation of the film area at the macroscopic level (ca. 10-100 cm2). DNA origami sheets were conjugated with a cationic lipid (dioctadecyldimethylammonium bromide, 2C18N+) by electrostatic interaction and the corresponding LB-film was prepared. By applying dynamic pressure variation through compression-expansion processes, the lipid-modified DNA origami sheets underwent anisotropic polymerization forming a one-dimensionally assembled belt-shaped structure of a high aspect ratio although the thickness of the polymerized DNA origami was maintained at the unimolecular level. This approach opens up a new field of mechanical induction of the self-assembly of DNA origami structures.

Original languageEnglish
Pages (from-to)12576-12581
Number of pages6
JournalPhysical Chemistry Chemical Physics
Volume18
Issue number18
DOIs
Publication statusPublished - 2016 Jan 1

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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