Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock

Hidekazu Shirota, Ihsan Gursel, Mayda Gursel, Dennis M. Klinman

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Endotoxic shock is a life-threatening condition caused by exposure to bacterial LPS. LPS triggers the release of acute phase, proinflammatory, and Th1 cytokines that facilitate the development of endotoxic shock. Synthetic oligodeoxynucleotides (ODN) expressing suppressive TTAGGG motifs effectively down-regulate the production of proinflammatory and Th1 cytokines elicited by a variety of immune stimuli. The current results demonstrate that suppressive ODN protect mice from LPS-induced endotoxic shock. Underlying this protective effect is the ability of suppressive ODN to bind to and prevent the phosphorylation of STAT1 and STAT4, thereby blocking the signaling cascade mediated by LPS-induced IFN-β and IL-12. These findings suggest that suppressive ODN might be of use in the treatment of endotoxic shock.

Original languageEnglish
Pages (from-to)4579-4583
Number of pages5
JournalJournal of Immunology
Volume174
Issue number8
DOIs
Publication statusPublished - 2005 Apr 15

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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