Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period

Yoshio Hosoi, K. Sakamoto

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The dose dependency and effective period of suppressive effects by low dose total body irradiation (TBI) in both artificial and spontaneous lung metastasis were investigated using marine squamous cell carcinoma. In the artificial lung metastasis of the tumour cells injected through a tail vein, the TBI of 0.15-0.20 Gy resulted in significant net suppression of lung colony formation. With this dose range, the effective period lasted for 12 h ranging from 9 h before to 3 h after the tumour cell injection. Similar suppressive effect was also observed in the spontaneous lung metastasis. These data suggest that careful assessment of effective dose and duration of low dose TBI on human metastasis could provide a new therapy to suppress clinical metastasis.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalRadiotherapy and Oncology
Volume26
Issue number2
DOIs
Publication statusPublished - 1993 Jan 1

Keywords

  • Low dose
  • Metastasis
  • Total body irradiation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period'. Together they form a unique fingerprint.

  • Cite this