Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production

YOSHIMI NIWANO; THOMAS R. HANSEN; MOHAMMAD KAZEMI; PUTHAN‐VEEDU ‐V MALATHY; HAROLD D. JOHNSON; R. MICHAEL ROBERTS; KAZUHIKO IMAKAWA

doi:10.1111/j.1600-0897.1989.tb00632.x

Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production

YOSHIMI NIWANO, THOMAS R. HANSEN, MOHAMMAD KAZEMI, PUTHAN‐VEEDU ‐V MALATHY, HAROLD D. JOHNSON, R. MICHAEL ROBERTS, KAZUHIKO IMAKAWA

Dentistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

ABSTRACT: Cells derived from the trophoblast tissue of a day 15 sheep conceptus released substances that inhibit incorporation of [³H]thymidine into phytohemagglutinin (PHA)‐stimulated ovine lymphocytes. This effect was partially reversed by addition of antiserum to ovine trophoblast protein‐1 (oTP‐1), a major secretory product of day 13–21 sheep conceptuses and a protein structurally and functionally related to α‐interferons (IFN‐α). Human IFN‐a, unlike dexamethasone, inhibits phytohemagglutinin‐induced lymphocyte blastogenesis without reducing interleukin‐2 (IL‐2) production by the cultures, and conditioned medium containing IL‐2 does not promote [³H]thymidine incorporation into ovine lymphocytes when oTP‐1 is present. Thus, oTP‐1, by virtue of being an IFN, may have a local immunomodulatory role by selectively inhibiting the proliferative responses of certain maternal immune cells to IL‐2. 1989 Munksgaard

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	American Journal of Reproductive Immunology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0897.1989.tb00632.x
Publication status	Published - 1989 May

Keywords

Ovine trophoblast protein‐1
embryo
interferon‐α
interleukin‐2
pregnancy

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynaecology

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NIWANO, YOSHIMI., HANSEN, THOMAS. R., KAZEMI, MOHAMMAD., MALATHY, PUTHANVEEDU. V., JOHNSON, HAROLD. D., ROBERTS, R. MICHAEL., & IMAKAWA, KAZUHIKO. (1989). Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production. American Journal of Reproductive Immunology, 20(1), 21-26. https://doi.org/10.1111/j.1600-0897.1989.tb00632.x

Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production. / NIWANO, YOSHIMI; HANSEN, THOMAS R.; KAZEMI, MOHAMMAD; MALATHY, PUTHAN‐VEEDU ‐V; JOHNSON, HAROLD D.; ROBERTS, R. MICHAEL; IMAKAWA, KAZUHIKO.

In: American Journal of Reproductive Immunology, Vol. 20, No. 1, 05.1989, p. 21-26.

Research output: Contribution to journal › Article › peer-review

NIWANO, YOSHIMI, HANSEN, THOMASR, KAZEMI, MOHAMMAD, MALATHY, PUTHANVEEDUV, JOHNSON, HAROLDD, ROBERTS, RMICHAEL & IMAKAWA, KAZUHIKO 1989, 'Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production', American Journal of Reproductive Immunology, vol. 20, no. 1, pp. 21-26. https://doi.org/10.1111/j.1600-0897.1989.tb00632.x

NIWANO YOSHIMI, HANSEN THOMASR, KAZEMI MOHAMMAD, MALATHY PUTHANVEEDUV, JOHNSON HAROLDD, ROBERTS RMICHAEL et al. Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production. American Journal of Reproductive Immunology. 1989 May;20(1):21-26. https://doi.org/10.1111/j.1600-0897.1989.tb00632.x

NIWANO, YOSHIMI ; HANSEN, THOMAS R. ; KAZEMI, MOHAMMAD ; MALATHY, PUTHAN‐VEEDU ‐V ; JOHNSON, HAROLD D. ; ROBERTS, R. MICHAEL ; IMAKAWA, KAZUHIKO. / Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production. In: American Journal of Reproductive Immunology. 1989 ; Vol. 20, No. 1. pp. 21-26.

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