Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production

YOSHIMI NIWANO, THOMAS R. HANSEN, MOHAMMAD KAZEMI, PUTHAN‐VEEDU ‐V MALATHY, HAROLD D. JOHNSON, R. MICHAEL ROBERTS, KAZUHIKO IMAKAWA

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23 Citations (Scopus)

Abstract

ABSTRACT: Cells derived from the trophoblast tissue of a day 15 sheep conceptus released substances that inhibit incorporation of [3H]thymidine into phytohemagglutinin (PHA)‐stimulated ovine lymphocytes. This effect was partially reversed by addition of antiserum to ovine trophoblast protein‐1 (oTP‐1), a major secretory product of day 13–21 sheep conceptuses and a protein structurally and functionally related to α‐interferons (IFN‐α). Human IFN‐a, unlike dexamethasone, inhibits phytohemagglutinin‐induced lymphocyte blastogenesis without reducing interleukin‐2 (IL‐2) production by the cultures, and conditioned medium containing IL‐2 does not promote [3H]thymidine incorporation into ovine lymphocytes when oTP‐1 is present. Thus, oTP‐1, by virtue of being an IFN, may have a local immunomodulatory role by selectively inhibiting the proliferative responses of certain maternal immune cells to IL‐2. 1989 Munksgaard

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Volume20
Issue number1
DOIs
Publication statusPublished - 1989 May

Keywords

  • Ovine trophoblast protein‐1
  • embryo
  • interferon‐α
  • interleukin‐2
  • pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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