TY - JOUR
T1 - Suppression of T‐Lymphocyte Blastogenesis by Ovine Trophoblast Protein‐1 and Human Interferon‐α May Be Independent of Interleukin‐2 Production
AU - NIWANO, YOSHIMI
AU - HANSEN, THOMAS R.
AU - KAZEMI, MOHAMMAD
AU - MALATHY, PUTHAN‐VEEDU ‐V
AU - JOHNSON, HAROLD D.
AU - ROBERTS, R. MICHAEL
AU - IMAKAWA, KAZUHIKO
PY - 1989/5
Y1 - 1989/5
N2 - ABSTRACT: Cells derived from the trophoblast tissue of a day 15 sheep conceptus released substances that inhibit incorporation of [3H]thymidine into phytohemagglutinin (PHA)‐stimulated ovine lymphocytes. This effect was partially reversed by addition of antiserum to ovine trophoblast protein‐1 (oTP‐1), a major secretory product of day 13–21 sheep conceptuses and a protein structurally and functionally related to α‐interferons (IFN‐α). Human IFN‐a, unlike dexamethasone, inhibits phytohemagglutinin‐induced lymphocyte blastogenesis without reducing interleukin‐2 (IL‐2) production by the cultures, and conditioned medium containing IL‐2 does not promote [3H]thymidine incorporation into ovine lymphocytes when oTP‐1 is present. Thus, oTP‐1, by virtue of being an IFN, may have a local immunomodulatory role by selectively inhibiting the proliferative responses of certain maternal immune cells to IL‐2. 1989 Munksgaard
AB - ABSTRACT: Cells derived from the trophoblast tissue of a day 15 sheep conceptus released substances that inhibit incorporation of [3H]thymidine into phytohemagglutinin (PHA)‐stimulated ovine lymphocytes. This effect was partially reversed by addition of antiserum to ovine trophoblast protein‐1 (oTP‐1), a major secretory product of day 13–21 sheep conceptuses and a protein structurally and functionally related to α‐interferons (IFN‐α). Human IFN‐a, unlike dexamethasone, inhibits phytohemagglutinin‐induced lymphocyte blastogenesis without reducing interleukin‐2 (IL‐2) production by the cultures, and conditioned medium containing IL‐2 does not promote [3H]thymidine incorporation into ovine lymphocytes when oTP‐1 is present. Thus, oTP‐1, by virtue of being an IFN, may have a local immunomodulatory role by selectively inhibiting the proliferative responses of certain maternal immune cells to IL‐2. 1989 Munksgaard
KW - Ovine trophoblast protein‐1
KW - embryo
KW - interferon‐α
KW - interleukin‐2
KW - pregnancy
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U2 - 10.1111/j.1600-0897.1989.tb00632.x
DO - 10.1111/j.1600-0897.1989.tb00632.x
M3 - Article
C2 - 2818821
AN - SCOPUS:0024414983
VL - 20
SP - 21
EP - 26
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
SN - 8755-8920
IS - 1
ER -