Suppression of CDDP-induced renal toxicity by sodium selenite

M. Yokoyama, A. Naganuma, N. Imura

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

CDDP is a strong anti-cancer agent, but impairs renal function. Since the selenium has been known to reduce the renal toxicity of mercury, the effect of selenium on the adverse action of CDDP was examined in mice. Remarkable protective action of sodium selenite was demonstrated against lethal and renal toxicity of CDDP. Furthermore, addition of selenite did not impair the anti-cancer action of CDDP. Morphological diminution of renal damage by selenite was evident by light and electron microscopic study. The results suggest that selenite decreases renal toxicity of CDDP without impairing its anti-tumor action.

Original languageEnglish
Pages (from-to)1225-1230
Number of pages6
JournalGan no rinsho. Japan journal of cancer clinics
Volume31
Issue number9 Suppl
Publication statusPublished - 1985 Jul 1

ASJC Scopus subject areas

  • Medicine(all)

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