Suppression of bradykinin-induced renin release by indomethacin in anesthetized rats

Mizue Suzuki, Susumu Satoh

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The present study was designed to investigate the effect of bradykinin on renin release in relation to prostaglandins by use of indomethacin, a cyclooxygenase inhibitor, in pentobarbital-anesthetized rats. A nonhypotensive dose of bradykinin (1 μg/kg. min), which was infused intrarenally, significantly increased plasma renin activity approximately 1.8-fold as compared to the control period. In indomethacin (5 mg/kg, i.v.)-pretreated rats, bradykinin did not significantly increase plasma renin activity. These results suggest that bradykinin does not directly increase plasma renin activity and that prostaglandins may participate in the bradykinin-induced renin release under these experimental conditions

Original languageEnglish
Pages (from-to)1227-1235
Number of pages9
JournalClinical and Experimental Hypertension
VolumeA6
Issue number6
DOIs
Publication statusPublished - 1984

Keywords

  • Bradykinin
  • Indomethacin
  • Plasma renin activity
  • Prostaglandins

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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