Abstract
Tocopherol (Toc) such as α-Toc has been expected to act as photochemopreventive agent of skin, but the effect of the other vitamin E forms [tocotrienols (T3)] has not been fully understood. We evaluated the anti-inflammatory effect of T3 on UVB-induced inflammatory reaction using immortalized human keratinocytes and hairless mice. γ-T3 suppressed UVB-induced PGE2 production while similar ±-Toc doses had no effect. The anti-inflammatory actions of γ-T3 were explained by its ability to reduce UVB-induced inflammatory gene and protein expression [cyclooxgenase-2 (COX-2), interleukin (IL)-1β, IL-6, and monocyte chemotactic protein-1]. Western blot analysis revealed γ-T3 inhibited p38, extracellular signal-regulated kinase, and c-Jun N-terminal kinase/stress-activated protein kinase activation. In HR-1 hairless mice, oral T3 suppressed UVB-induced changes in skin thickness, COX-2 protein expression, and hyperplasia, but α-Toc did not. These results suggest T3 has potential use to protect against UVB-induced skin inflammation.
Original language | English |
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Pages (from-to) | 7013-7020 |
Number of pages | 8 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 58 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2010 Jun 9 |
Keywords
- Cyclooxgenase-2
- HaCaT
- Tocopherol
- Tocotrienol
- UVB
ASJC Scopus subject areas
- Chemistry(all)
- Agricultural and Biological Sciences(all)