Suppression by glucocorticoid of the immunoreactivity of corticotropin-releasing factor and vasopressin in the paraventricular nucleus of rat hypothalamus

Keiichi Itoi, Toraichi Mouri, Kazuhiro Takahashi, Osamu Murakami, Yutaka Imai, Shuichi Sasaki, Kaoru Yoshinaga, Nobuaki Sasano

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41 Citations (Scopus)

Abstract

The effect of glucocorticoid on the production of corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus of the hypothalamus (PVH) was examined immunocytochemically. Intraperitoneal administration of dexamethasone sulfate in a dose of 0.1 mg/day suppressed the immunoreactivity of CRF and vasopressin in the medial parvocellular divisions of the PVH of the rat subsequent to bilateral adrenalectomy. In the magnocellular divisions, suppression of vasopressin-immunoreactivity was not observed. These results suggest that the vasopressin in the medial parvocellular divisions plays a distinct role from that in the magnocellular divisions, the former having functional significance in the hypothalamo-hypophysio-adrenal axis.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalNeuroscience Letters
Volume73
Issue number3
DOIs
Publication statusPublished - 1987 Jan 27

Keywords

  • Corticotropin-releasing factor
  • Glucocorticoid
  • Hypothalamus
  • Immunocytochemistry
  • Paraventricular nucleus
  • Rat brain
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)

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