Suppressed peripheral blood lymphocyte blastogenesis in pre- and postpartal sheep by chronic heat-stress, and suppressive property of heat-stressed sheep serum on lymphocytes

Yoshimi Niwano, B. Ann Becker, Ranadhir Mitra, Charles W. Caldwell, Esmat B. Abdalla, Harold D. Johnson

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Phytohemagglutinin (PHA) and concanavalin A (Con A)-induced blastogenesis of peripheral blood lymphocytes was examined in heat-stressed pre- and postpartal sheep. The peak responses of lymphocytes to PHA and Con A in heat-stressed sheep revealed significant reduction before and after parturition compared with those in the corresponding control animals kept under thermoneutral conditions. Furthermore, the effect of serum from control or heat-stressed sheep on PHA-induced lymphocyte blastogenesis was examined. Supplementation of serum from heat-stressed sheep significantly suppressed the blastogenesis of lymphocytes obtained from healthy sheep, bovine, and human donors. Unlike dexamethasone, heat-stressed sheep serum did not inhibit IL-2 production by PHA-stimulated human peripheral blood lymphocytes. These results indicate that the immunosuppression of heat-stressed sheep is in part mediated by serum factor(s) that can modulate T-cell function in a species nonspecific manner.

Original languageEnglish
Pages (from-to)139-149
Number of pages11
JournalDevelopmental and Comparative Immunology
Volume14
Issue number1
DOIs
Publication statusPublished - 1990 Jan 1

Keywords

  • Blastogenesis
  • Dexamethasone
  • Immunosuppression
  • Lymphocytes
  • Parturition
  • T-cell function

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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