Supercritical carbon dioxide extraction of α-mangostin from mangosteen pericarp with virgin coconut oil as co-extractant and in-vitro bio-accessibility measurement

Wan Jun Lee; Chea Chi Ng; Jin Shuen Ng; Richard Lee Smith; Siew Lee Kok; Yen Yi Hee; Sin Yee Lee; Wei Kiat Tan; Nur Hanani Zainal Abidin; Sarina Abdul Halim Lim; Gun Hean Chong

doi:10.1016/j.procbio.2019.09.009

Supercritical carbon dioxide extraction of α-mangostin from mangosteen pericarp with virgin coconut oil as co-extractant and in-vitro bio-accessibility measurement

Wan Jun Lee, Chea Chi Ng, Jin Shuen Ng, Richard Lee Smith, Siew Lee Kok, Yen Yi Hee, Sin Yee Lee, Wei Kiat Tan, Nur Hanani Zainal Abidin, Sarina Abdul Halim Lim, Gun Hean Chong

ENV - Frontier Science for Advanced Environment

Research output: Contribution to journal › Article › peer-review

Abstract

This work aims to develop a method for producing α-mangostin that has high bio-accessibility through the use of supercritical carbon dioxide (scCO₂) extraction of mangosteen pericarp extract (MPE) with virgin coconut oil (VCO) as co-extractant. Extractions with scCO₂ were carried out at 30 MPa to 40 MPa, 60 °C, CO₂ flow rate of 1.7 g/min and co-extractant VCO (0% to 20%). MPE yield and extraction yield increased with the amount of co-extractant added. The highest yield of MPE obtained was 17% at conditions of 35 MPa with 20% of VCO. The scCO₂ MPE had higher bio-accessibility for α-mangostin (91%) than α-mangostin obtained by extraction with ethanol (30%) or hexane (50%). Thus, supercritical CO₂ extraction used with virgin coconut oil co-extractant provides a method for producing high bio-accessible α-mangostin from mangosteen pericarp extract.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Process Biochemistry
Volume	87
DOIs	https://doi.org/10.1016/j.procbio.2019.09.009
Publication status	Published - 2019 Dec

Keywords

Bio-accessibility
Co-extractant
Garcinia mangostana Linn
Supercritical fluid extraction
Virgin coconut oil
Xanthone

ASJC Scopus subject areas

Bioengineering
Biochemistry
Applied Microbiology and Biotechnology

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Lee, W. J., Ng, C. C., Ng, J. S., Smith, R. L., Kok, S. L., Hee, Y. Y., Lee, S. Y., Tan, W. K., Zainal Abidin, N. H., Halim Lim, S. A., & Chong, G. H. (2019). Supercritical carbon dioxide extraction of α-mangostin from mangosteen pericarp with virgin coconut oil as co-extractant and in-vitro bio-accessibility measurement. Process Biochemistry, 87, 213-220. https://doi.org/10.1016/j.procbio.2019.09.009

Supercritical carbon dioxide extraction of α-mangostin from mangosteen pericarp with virgin coconut oil as co-extractant and in-vitro bio-accessibility measurement. / Lee, Wan Jun; Ng, Chea Chi; Ng, Jin Shuen; Smith, Richard Lee; Kok, Siew Lee; Hee, Yen Yi; Lee, Sin Yee; Tan, Wei Kiat; Zainal Abidin, Nur Hanani; Halim Lim, Sarina Abdul; Chong, Gun Hean.

In: Process Biochemistry, Vol. 87, 12.2019, p. 213-220.

Research output: Contribution to journal › Article › peer-review

Lee, WJ, Ng, CC, Ng, JS, Smith, RL, Kok, SL, Hee, YY, Lee, SY, Tan, WK, Zainal Abidin, NH, Halim Lim, SA & Chong, GH 2019, 'Supercritical carbon dioxide extraction of α-mangostin from mangosteen pericarp with virgin coconut oil as co-extractant and in-vitro bio-accessibility measurement', Process Biochemistry, vol. 87, pp. 213-220. https://doi.org/10.1016/j.procbio.2019.09.009

Lee, Wan Jun ; Ng, Chea Chi ; Ng, Jin Shuen ; Smith, Richard Lee ; Kok, Siew Lee ; Hee, Yen Yi ; Lee, Sin Yee ; Tan, Wei Kiat ; Zainal Abidin, Nur Hanani ; Halim Lim, Sarina Abdul ; Chong, Gun Hean. / Supercritical carbon dioxide extraction of α-mangostin from mangosteen pericarp with virgin coconut oil as co-extractant and in-vitro bio-accessibility measurement. In: Process Biochemistry. 2019 ; Vol. 87. pp. 213-220.

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abstract = "This work aims to develop a method for producing α-mangostin that has high bio-accessibility through the use of supercritical carbon dioxide (scCO2) extraction of mangosteen pericarp extract (MPE) with virgin coconut oil (VCO) as co-extractant. Extractions with scCO2 were carried out at 30 MPa to 40 MPa, 60 °C, CO2 flow rate of 1.7 g/min and co-extractant VCO (0% to 20%). MPE yield and extraction yield increased with the amount of co-extractant added. The highest yield of MPE obtained was 17% at conditions of 35 MPa with 20% of VCO. The scCO2 MPE had higher bio-accessibility for α-mangostin (91%) than α-mangostin obtained by extraction with ethanol (30%) or hexane (50%). Thus, supercritical CO2 extraction used with virgin coconut oil co-extractant provides a method for producing high bio-accessible α-mangostin from mangosteen pericarp extract.",

keywords = "Bio-accessibility, Co-extractant, Garcinia mangostana Linn, Supercritical fluid extraction, Virgin coconut oil, Xanthone",

author = "Lee, {Wan Jun} and Ng, {Chea Chi} and Ng, {Jin Shuen} and Smith, {Richard Lee} and Kok, {Siew Lee} and Hee, {Yen Yi} and Lee, {Sin Yee} and Tan, {Wei Kiat} and {Zainal Abidin}, {Nur Hanani} and {Halim Lim}, {Sarina Abdul} and Chong, {Gun Hean}",

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AU - Smith, Richard Lee

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AU - Hee, Yen Yi

AU - Lee, Sin Yee

AU - Tan, Wei Kiat

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AU - Halim Lim, Sarina Abdul

AU - Chong, Gun Hean

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AB - This work aims to develop a method for producing α-mangostin that has high bio-accessibility through the use of supercritical carbon dioxide (scCO2) extraction of mangosteen pericarp extract (MPE) with virgin coconut oil (VCO) as co-extractant. Extractions with scCO2 were carried out at 30 MPa to 40 MPa, 60 °C, CO2 flow rate of 1.7 g/min and co-extractant VCO (0% to 20%). MPE yield and extraction yield increased with the amount of co-extractant added. The highest yield of MPE obtained was 17% at conditions of 35 MPa with 20% of VCO. The scCO2 MPE had higher bio-accessibility for α-mangostin (91%) than α-mangostin obtained by extraction with ethanol (30%) or hexane (50%). Thus, supercritical CO2 extraction used with virgin coconut oil co-extractant provides a method for producing high bio-accessible α-mangostin from mangosteen pericarp extract.

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