@article{caa92146f94a4aeeb944d8325b58ab39,
title = "Supercritical carbon dioxide extraction of α-mangostin from mangosteen pericarp with virgin coconut oil as co-extractant and in-vitro bio-accessibility measurement",
abstract = "This work aims to develop a method for producing α-mangostin that has high bio-accessibility through the use of supercritical carbon dioxide (scCO2) extraction of mangosteen pericarp extract (MPE) with virgin coconut oil (VCO) as co-extractant. Extractions with scCO2 were carried out at 30 MPa to 40 MPa, 60 °C, CO2 flow rate of 1.7 g/min and co-extractant VCO (0% to 20%). MPE yield and extraction yield increased with the amount of co-extractant added. The highest yield of MPE obtained was 17% at conditions of 35 MPa with 20% of VCO. The scCO2 MPE had higher bio-accessibility for α-mangostin (91%) than α-mangostin obtained by extraction with ethanol (30%) or hexane (50%). Thus, supercritical CO2 extraction used with virgin coconut oil co-extractant provides a method for producing high bio-accessible α-mangostin from mangosteen pericarp extract.",
keywords = "Bio-accessibility, Co-extractant, Garcinia mangostana Linn, Supercritical fluid extraction, Virgin coconut oil, Xanthone",
author = "Lee, {Wan Jun} and Ng, {Chea Chi} and Ng, {Jin Shuen} and Smith, {Richard Lee} and Kok, {Siew Lee} and Hee, {Yen Yi} and Lee, {Sin Yee} and Tan, {Wei Kiat} and {Zainal Abidin}, {Nur Hanani} and {Halim Lim}, {Sarina Abdul} and Chong, {Gun Hean}",
note = "Funding Information: This work was supported by Geran Putra ( GP-PI/2016/9481200 ), Universiti Putra Malaysia . Gratitude is expressed to Adirondack (M) Sdn. Bhd (Selangor, Malaysia) for the free supply of dried mangosteen pericarp and virgin coconut oil that were used in this work. The authors acknowledge collaborative effort on the project through the MoU between Department of Food Technology, Supercritical Fluid Centre (Universiti Putra Malaysia) and Research Center of Supercritical Fluid Technology (Tohoku University). Funding Information: This work was supported by Geran Putra (GP-PI/2016/9481200), Universiti Putra Malaysia. Gratitude is expressed to Adirondack (M) Sdn. Bhd (Selangor, Malaysia) for the free supply of dried mangosteen pericarp and virgin coconut oil that were used in this work. The authors acknowledge collaborative effort on the project through the MoU between Department of Food Technology, Supercritical Fluid Centre (Universiti Putra Malaysia) and Research Center of Supercritical Fluid Technology (Tohoku University). Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = dec,
doi = "10.1016/j.procbio.2019.09.009",
language = "English",
volume = "87",
pages = "213--220",
journal = "Process Biochemistry",
issn = "0032-9592",
publisher = "Elsevier BV",
}