Supercooled micro flows and application for asymmetric synthesis

Shinya Matsuoka, Akihide Hibara, Masaharu Ueno, Takehiko Kitamori

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Supercooled micro flow in microchannels was demonstrated. In order to clarify fundamental properties of the supercooling state in microchannels, freezing temperature was measured in the microchannels having widths ranging from 70 μm to 300 μm. The freezing temperature decreased with decreasing width of the microchannel when the microchannel wall was chemically modified with octadecylsilane group. The lowest freezing temperature was observed as -28°C for water in the 70 μm wide microchannel. By contrast, the freezing temperature was -15°C and did not depend on width when a microchannel with a bare glass surface was used. Next, the freezing point was measured with flow rates ranging from 0.1 to 2.0 μl min-1 and no dependence on flow rate was observed. Then, the supercooled micro flow was applied to an asymmetric reaction in micro two-phase flow of aqueous and CH2Cl2 phases. As expected from thermodynamic prediction, enantiomeric selectivity increased in the supercooled state of water.

Original languageEnglish
Pages (from-to)1236-1238
Number of pages3
JournalLab on a Chip
Volume6
Issue number9
DOIs
Publication statusPublished - 2006 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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