The Super ODS steels, having excellent high-temperature strength and highly corrosion resistant, are considered to increase the energy efficiency by higher temperature operation and extend the lifetime of next generation nuclear systems. High-temperature strength of the ODS steels strongly depends on the dispersion of oxide particles, therefore, the irradiation effect on the dispersed oxides is critical in the material development. In the present research, ion irradiation experiments were employed to investigate microstructural stability under the irradiation environment at elevated temperatures. Ion irradiation experiments were performed with 6.4 MeV Fe ions irradiated at 650 °C up to a nominal displacement damage of 60 dpa. Microstructural investigation was carried out using TEM and EDX. No significant change of grains and grain boundaries was observed by TEM investigation after the ion irradiation. Main oxide particles in the 16Cr-4Al-0.1Ti (SOC-1) ODS steel were (Y, Al) complex oxides. (Y, Ti) complex oxides were in 16Cr-0.1Ti (SOC-5) and 15.5Cr-2W-0.1Ti (SOCP-3). (Y, Zr) complex oxides were in 15.5Cr-4Al-0.6Zr (SOCP-1). No significant modification of these complex oxides was detected after the ion irradiation up to 60 dpa at 650 °C. The stable complex oxides are considered to keep highly microstructural stability of the Super ODS steels under the irradiation environments.