1HMRI detection of gene expression in living cells by using protein tag and biotinylation probe

Akimasa Yoshimura, Shin Mizukami, Yuki Mori, Yoshichika Yoshioka, Kazuya Kikuchi

Research output: Contribution to journalArticlepeer-review

Abstract

A new detection method for gene expression by magnetic resonance imaging (MRI) was developed using a proteinlabeling system based on a noncatalytic mutant β-lactamase (BL-tag system). By combining the BL-tag system with a specific biotinylation probe and a streptavidin-conjugated superparamagnetic iron oxide, target gene expression in living cells was successful detected by 1HMRI.

Original languageEnglish
Pages (from-to)219-221
Number of pages3
JournalChemistry Letters
Volume43
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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