@article{f078ea52010a4e0685ce4f8d02ea0078,
title = "[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer{\textquoteright}s disease",
abstract = "Purpose: Visualization of the spatial distribution of neurofibrillary tangles would help in the diagnosis, prevention and treatment of dementia. The purpose of the study was to evaluate the clinical utility of [18F]THK-5117 as a highly selective tau imaging radiotracer. Methods: We initially evaluated in vitro binding of [3H]THK-5117 in post-mortem brain tissues from patients with Alzheimer{\textquoteright}s disease (AD). In clinical PET studies, [18F]THK-5117 retention in eight patients with AD was compared with that in six healthy elderly controls. Ten subjects underwent an additional [11C]PiB PET scan within 2 weeks. Results: In post-mortem brain samples, THK-5117 bound selectively to neurofibrillary deposits, which differed from the binding target of PiB. In clinical PET studies, [18F]THK-5117 binding in the temporal lobe clearly distinguished patients with AD from healthy elderly subjects. Compared with [11C]PiB, [18F]THK-5117 retention was higher in the medial temporal cortex. Conclusion: These findings suggest that [18F]THK-5117 provides regional information on neurofibrillary pathology in living subjects.",
keywords = "Alzheimer{\textquoteright}s disease, Imaging, Neurofibrillary tangles, PET, Tau, [F]THK-5117",
author = "Ryuichi Harada and Nobuyuki Okamura and Shozo Furumoto and Katsutoshi Furukawa and Aiko Ishiki and Naoki Tomita and Kotaro Hiraoka and Shoichi Watanuki and Miho Shidahara and Masayasu Miyake and Yoichi Ishikawa and Rin Matsuda and Akie Inami and Takeo Yoshikawa and Tetsuro Tago and Yoshihito Funaki and Ren Iwata and Manabu Tashiro and Kazuhiko Yanai and Hiroyuki Arai and Yukitsuka Kudo",
note = "Funding Information: Yukitsuka Kudo, Nobuyuki Okamura and Shozo Furumoto received research grants from GE Healthcare. Yukitsuka Kudo also received research grants from Sumitomo Electric Industries. Yukitsuka Kudo and Nobuyuki Okamura own stock in Clino Ltd. Funding Information: This study was supported by the research fund from GE Healthcare, the SEI (Sumitomo Electric Industries, Ltd.) Group CSR Foundation, the Industrial Technology Research Grant Program of the NEDO in Japan (09E51025a), Health and Labor Sciences Research Grants from the Ministry of Health, Labor, and Welfare of Japan, a Grant-in-Aid for Scientific Research (B) (23390297), a Grant-in-Aid for Scientific Research on Innovative Areas (26117003) and “Japan Advanced Molecular Imaging Program (J-AMP)” of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Publisher Copyright: {\textcopyright} 2015, Springer-Verlag Berlin Heidelberg.",
year = "2015",
month = jun,
day = "1",
doi = "10.1007/s00259-015-3035-4",
language = "English",
volume = "42",
pages = "1052--1061",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Springer Verlag",
number = "7",
}