Purpose: Visualization of the spatial distribution of neurofibrillary tangles would help in the diagnosis, prevention and treatment of dementia. The purpose of the study was to evaluate the clinical utility of [18F]THK-5117 as a highly selective tau imaging radiotracer. Methods: We initially evaluated in vitro binding of [3H]THK-5117 in post-mortem brain tissues from patients with Alzheimer’s disease (AD). In clinical PET studies, [18F]THK-5117 retention in eight patients with AD was compared with that in six healthy elderly controls. Ten subjects underwent an additional [11C]PiB PET scan within 2 weeks. Results: In post-mortem brain samples, THK-5117 bound selectively to neurofibrillary deposits, which differed from the binding target of PiB. In clinical PET studies, [18F]THK-5117 binding in the temporal lobe clearly distinguished patients with AD from healthy elderly subjects. Compared with [11C]PiB, [18F]THK-5117 retention was higher in the medial temporal cortex. Conclusion: These findings suggest that [18F]THK-5117 provides regional information on neurofibrillary pathology in living subjects.
|Number of pages||10|
|Journal||European journal of nuclear medicine and molecular imaging|
|Publication status||Published - 2015 Jun 1|
- Alzheimer’s disease
- Neurofibrillary tangles
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging