[18F]fluoride was produced via the 18O(p,n)18F reaction with a circulating 20% enriched [18O]water target. Parameters affecting the production yield of [18F]fluoride such as beam current, beam profile, irradiation time, target thickness, circulation rate, and window material were investigated and optimized. With a 20 μA irradiation of 2.5 mL [18O]water circulated at a flow rate of over 35 mL/min, a [18F]fluoride yield of more than 70% was obtained when the beam was defocussed and wobbled to get a uniform beam profile. In addition, radiolytically produced gases were recombined using a Pd catalyst into the target.
|Number of pages||6|
|Journal||International Journal of Radiation Applications and Instrumentation. Part|
|Publication status||Published - 1987|
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