[18F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations

A. Bogni, C. Pascali, R. Iwata, A. Cavalleri, V. De Sanctis, D. Decise, G. Cucchetti, F. Crippa, C. Chiesa, M. Schiavini, E. Bombardieri

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, "one-pot" reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.

    Original languageEnglish
    Pages (from-to)45-51
    Number of pages7
    JournalJournal of Radioanalytical and Nuclear Chemistry
    Volume230
    Issue number1-2
    Publication statusPublished - 1998 Jan 1

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Nuclear Energy and Engineering
    • Radiology Nuclear Medicine and imaging
    • Pollution
    • Spectroscopy
    • Public Health, Environmental and Occupational Health
    • Health, Toxicology and Mutagenesis

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