TY - JOUR
T1 - [18F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism
AU - Chida, Masanobu
AU - Kagaya, Yutaka
AU - Nagata, Shinji
AU - Mukoyoshi, Masanori
AU - Namiuchi, Shigeto
AU - Yamane, Yuriko
AU - Ishide, Nobumasa
AU - Watanabe, Jun
AU - Takahashi, Toshihiro
AU - Ido, Tatsuo
AU - Shirato, Kunio
PY - 2001
Y1 - 2001
N2 - Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [18F]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[18F]fluorooctanoyl]-2-palmitoylglycerol and 1-[8-[18F]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacylglycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection.
AB - Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [18F]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[18F]fluorooctanoyl]-2-palmitoylglycerol and 1-[8-[18F]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacylglycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection.
KW - Myocardium
KW - Phosphoinositide metabolism
KW - Positron emission tomography
KW - [F]diacylglycerol
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U2 - 10.1016/S0969-8051(01)00250-5
DO - 10.1016/S0969-8051(01)00250-5
M3 - Article
C2 - 11578903
AN - SCOPUS:0034741135
VL - 28
SP - 815
EP - 819
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 7
ER -