[18F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism

Masanobu Chida, Yutaka Kagaya, Shinji Nagata, Masanori Mukoyoshi, Shigeto Namiuchi, Yuriko Yamane, Nobumasa Ishide, Jun Watanabe, Toshihiro Takahashi, Tatsuo Ido, Kunio Shirato

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [18F]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[18F]fluorooctanoyl]-2-palmitoylglycerol and 1-[8-[18F]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacylglycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection.

Original languageEnglish
Pages (from-to)815-819
Number of pages5
JournalNuclear Medicine and Biology
Volume28
Issue number7
DOIs
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Myocardium
  • Phosphoinositide metabolism
  • Positron emission tomography
  • [F]diacylglycerol

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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