[18F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism

Masanobu Chida; Yutaka Kagaya; Shinji Nagata; Masanori Mukoyoshi; Shigeto Namiuchi; Yuriko Yamane; Nobumasa Ishide; Jun Watanabe; Toshihiro Takahashi; Tatsuo Ido; Kunio Shirato

doi:10.1016/S0969-8051(01)00250-5

[¹⁸F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism

Masanobu Chida, Yutaka Kagaya, Shinji Nagata, Masanori Mukoyoshi, Shigeto Namiuchi, Yuriko Yamane, Nobumasa Ishide, Jun Watanabe, Toshihiro Takahashi, Tatsuo Ido, Kunio Shirato

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [¹⁸F]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[¹⁸F]fluorooctanoyl]-2-palmitoylglycerol and 1-[8-[¹⁸F]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacylglycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[¹⁸F]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[¹⁸F]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection.

Original language	English
Pages (from-to)	815-819
Number of pages	5
Journal	Nuclear Medicine and Biology
Volume	28
Issue number	7
DOIs	https://doi.org/10.1016/S0969-8051(01)00250-5
Publication status	Published - 2001
Externally published	Yes

Keywords

Myocardium
Phosphoinositide metabolism
Positron emission tomography
[F]diacylglycerol

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0969-8051(01)00250-5

Cite this

[¹⁸F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism. / Chida, Masanobu; Kagaya, Yutaka; Nagata, Shinji; Mukoyoshi, Masanori; Namiuchi, Shigeto; Yamane, Yuriko; Ishide, Nobumasa; Watanabe, Jun; Takahashi, Toshihiro; Ido, Tatsuo; Shirato, Kunio.

In: Nuclear Medicine and Biology, Vol. 28, No. 7, 2001, p. 815-819.

Research output: Contribution to journal › Article › peer-review

Chida, Masanobu ; Kagaya, Yutaka ; Nagata, Shinji ; Mukoyoshi, Masanori ; Namiuchi, Shigeto ; Yamane, Yuriko ; Ishide, Nobumasa ; Watanabe, Jun ; Takahashi, Toshihiro ; Ido, Tatsuo ; Shirato, Kunio. / [¹⁸F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism. In: Nuclear Medicine and Biology. 2001 ; Vol. 28, No. 7. pp. 815-819.

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AU - Namiuchi, Shigeto

AU - Yamane, Yuriko

AU - Ishide, Nobumasa

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AU - Ido, Tatsuo

AU - Shirato, Kunio

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AB - Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [18F]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[18F]fluorooctanoyl]-2-palmitoylglycerol and 1-[8-[18F]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacylglycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection.

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KW - [F]diacylglycerol

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