18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies

X. S. Hu, N. Okamura, Hiroyuki Arai, M. Higuchi, T. Matsui, Manabu Tashiro, M. Shinkawa, Masatoshi Itoh, T. Ido, H. Sasaki

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Using 18F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with 18F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.

Original languageEnglish
Pages (from-to)1575-1576
Number of pages2
JournalNeurology
Volume55
Issue number10
Publication statusPublished - 2000 Nov 28

ASJC Scopus subject areas

  • Clinical Neurology

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