15N-15N J-coupling across HgII: Direct observation of HgII-mediated T-T base pairs in a DNA duplex

Yoshiyuki Tanaka, Shuji Oda, Hiroshi Yamaguchi, Yoshinori Kondo, Chojiro Kojima, Akira Ono

Research output: Contribution to journalArticlepeer-review

446 Citations (Scopus)

Abstract

N-N J-coupling across a metal center (2JNN) was clearly detected in a biological macromolecule (DNA duplex) for the first time. By using 2JNN, the base pairing mode of mercury-mediatedT-T pairs (T-HgII-T) was definitely determined. This pairing mode was found to be a novel metal ion-binding mode for DNA and RNA molecules, in which imino proton-metal exchange processes are included. Accordingly, 2JNN is highly important for the determination of the chemical structures of metal-mediated base pairs.

Original languageEnglish
Pages (from-to)244-245
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number2
DOIs
Publication statusPublished - 2007 Jan 17

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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