15N-15N J-coupling across HgII: Direct observation of HgII-mediated T-T base pairs in a DNA duplex

Yoshiyuki Tanaka; Shuji Oda; Hiroshi Yamaguchi; Yoshinori Kondo; Chojiro Kojima; Akira Ono

doi:10.1021/ja065552h

¹⁵N-¹⁵N J-coupling across Hg^II: Direct observation of Hg^II-mediated T-T base pairs in a DNA duplex

Yoshiyuki Tanaka, Shuji Oda, Hiroshi Yamaguchi, Yoshinori Kondo, Chojiro Kojima, Akira Ono

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

446 Citations (Scopus)

Abstract

N-N J-coupling across a metal center (²J_NN) was clearly detected in a biological macromolecule (DNA duplex) for the first time. By using ²J_NN, the base pairing mode of mercury-mediatedT-T pairs (T-Hg^II-T) was definitely determined. This pairing mode was found to be a novel metal ion-binding mode for DNA and RNA molecules, in which imino proton-metal exchange processes are included. Accordingly, ²J_NN is highly important for the determination of the chemical structures of metal-mediated base pairs.

Original language	English
Pages (from-to)	244-245
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	2
DOIs	https://doi.org/10.1021/ja065552h
Publication status	Published - 2007 Jan 17

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "15N-15N J-coupling across HgII: Direct observation of HgII-mediated T-T base pairs in a DNA duplex",

abstract = "N-N J-coupling across a metal center (2JNN) was clearly detected in a biological macromolecule (DNA duplex) for the first time. By using 2JNN, the base pairing mode of mercury-mediatedT-T pairs (T-HgII-T) was definitely determined. This pairing mode was found to be a novel metal ion-binding mode for DNA and RNA molecules, in which imino proton-metal exchange processes are included. Accordingly, 2JNN is highly important for the determination of the chemical structures of metal-mediated base pairs.",

author = "Yoshiyuki Tanaka and Shuji Oda and Hiroshi Yamaguchi and Yoshinori Kondo and Chojiro Kojima and Akira Ono",

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AU - Oda, Shuji

AU - Yamaguchi, Hiroshi

AU - Kondo, Yoshinori

AU - Kojima, Chojiro

AU - Ono, Akira

PY - 2007/1/17

Y1 - 2007/1/17

N2 - N-N J-coupling across a metal center (2JNN) was clearly detected in a biological macromolecule (DNA duplex) for the first time. By using 2JNN, the base pairing mode of mercury-mediatedT-T pairs (T-HgII-T) was definitely determined. This pairing mode was found to be a novel metal ion-binding mode for DNA and RNA molecules, in which imino proton-metal exchange processes are included. Accordingly, 2JNN is highly important for the determination of the chemical structures of metal-mediated base pairs.

AB - N-N J-coupling across a metal center (2JNN) was clearly detected in a biological macromolecule (DNA duplex) for the first time. By using 2JNN, the base pairing mode of mercury-mediatedT-T pairs (T-HgII-T) was definitely determined. This pairing mode was found to be a novel metal ion-binding mode for DNA and RNA molecules, in which imino proton-metal exchange processes are included. Accordingly, 2JNN is highly important for the determination of the chemical structures of metal-mediated base pairs.

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¹⁵N-¹⁵N J-coupling across Hg^II: Direct observation of Hg^II-mediated T-T base pairs in a DNA duplex

Abstract

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