[11C]Labeling of coenzyme Q10 and its tissue distribution

T. Takahashi, T. Ido, R. Iwata, K. Ishiwata, K. Hamamura, K. Kogure

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    [11C]Coenzyme Q10 was synthesized by O‐methylation of 3‐demethyl coenzyme Q10 with 11CH3I. We have produced 1–4 mCi of [11C]coenzyme Q10 with radiochemical yields of 6–16 % (based on trapping 11CH3I) in 35–50 min with radiochemical purities of >95%. The specific activity was 4–5 mCi/μMol at the end of [11C]‐coenzyme Q10 synthesis. The tissue distribution was investigated on mongolian gerbils after intravenous administration of [11C]‐coenzyme Q10 solubilized with polyoxyethylene hydrogenated caster oil (HCO‐60). The blood level of [11C]coenzyme Q10 was very high and its clearance was slow. The accumulations in the heart, kidney and liver were moderate and the accumulation in the brain was low in spite of its high lipophilicity.

    Original languageEnglish
    Pages (from-to)565-575
    Number of pages11
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume22
    Issue number6
    DOIs
    Publication statusPublished - 1985 Jun

    Keywords

    • O‐Methylation
    • Tissue distribution
    • [C]Coenzyme Q

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

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