11C-methionine PET of acute myocardial infarction

Miyako Morooka, Kazuo Kubota, Hiromu Kadowaki, Kimiteru Ito, Osamu Okazaki, Mitsuo Kashida, Takuya Mitsumoto, Ren Iwata, Kuni Ohtomo, Michiaki Hiroe

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Tissue uptake of L-[methyl-11C]-methionine (11C- methionine) has been used to monitor amino acid metabolism and protein synthesis. We examined whether 11C-methionine was retained in areas of myocardial infarction after successful reperfusion. Methods: Nine patients with infarction in the left anterior descendent region underwent percutaneous transluminal coronary artery intervention within 24 h and 201Tl SPECT, 18F-FDG PET, and 11C-methionine PET within 2 wk of infarction onset. The standardized uptake values of the infarcted area and of the normal area were measured. Results: The 11C-methionine images showed increased uptake in the infarcted area, whereas the 201Tl SPECT and 18F-FDG PET images showed decreased uptake. The highest accumulation of 11C-methionine in the infarcted area was observed during the early phase of AMI. Conclusion: 11C-methionine uptake is elevated in infarcted areas and may reflect the early acute phase of damage healing, that is, the initial process of remodeling.

Original languageEnglish
Pages (from-to)1283-1287
Number of pages5
JournalJournal of Nuclear Medicine
Volume50
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1
Externally publishedYes

Keywords

  • C-methionine
  • F-FDG
  • Myocardial infarction
  • PET
  • Remodeling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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