11C-Coenzyme Q10: A new myocardial imaging tracer for positron emission tomography

Kiichi Ishiwata; Yuka Miura; Toshihiro Takahashi; Koichiro Kawashima; Kazuhiko Yanai; Minoru Monma; Tatsuo Ido

doi:10.1007/BF00251367

¹¹C-Coenzyme Q₁₀: A new myocardial imaging tracer for positron emission tomography

Kiichi Ishiwata, Yuka Miura, Toshihiro Takahashi, Koichiro Kawashima, Kazuhiko Yanai, Minoru Monma, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Coenzyme Q₁₀ (CoQ₁₀) is a co-factor of the mitochondrial electron-transfer system. ¹¹C-Labeled CoQ₁₀ was synthesized and its biodistribution in rats was examined comparing two kinds of preparation methods using different emulsifiers as a basic study for application of positron emission tomography. ¹¹C-CoQ₁₀ emulsified in saline with polyoxyethylene hydrogenated caster oil was present in the highest concentration in the blood at 30 min. On the other hand, the ¹¹C-CoQ₁₀ emulsified with phospholipids was rapidly cleared from the blood. The liver and spleen uptakes were high probably due to endocytosis, reflecting the characteristics of liposomes. The myocardial uptake was also high just after administration, and the heart-to-blood concentration ratio was over 10 after 5 min. These results suggest that ¹¹C-CoQ₁₀ prepared with liposomes may be a myocardial imaging tracer.

Original language	English
Pages (from-to)	162-165
Number of pages	4
Journal	European Journal of Nuclear Medicine
Volume	11
Issue number	5
DOIs	https://doi.org/10.1007/BF00251367
Publication status	Published - 1985 Oct
Externally published	Yes

Keywords

Coenzyme Q
Myocardial imaging
Positron

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/BF00251367

Cite this

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title = "11C-Coenzyme Q10: A new myocardial imaging tracer for positron emission tomography",

abstract = "Coenzyme Q10 (CoQ10) is a co-factor of the mitochondrial electron-transfer system. 11C-Labeled CoQ10 was synthesized and its biodistribution in rats was examined comparing two kinds of preparation methods using different emulsifiers as a basic study for application of positron emission tomography. 11C-CoQ10 emulsified in saline with polyoxyethylene hydrogenated caster oil was present in the highest concentration in the blood at 30 min. On the other hand, the 11C-CoQ10 emulsified with phospholipids was rapidly cleared from the blood. The liver and spleen uptakes were high probably due to endocytosis, reflecting the characteristics of liposomes. The myocardial uptake was also high just after administration, and the heart-to-blood concentration ratio was over 10 after 5 min. These results suggest that 11C-CoQ10 prepared with liposomes may be a myocardial imaging tracer.",

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author = "Kiichi Ishiwata and Yuka Miura and Toshihiro Takahashi and Koichiro Kawashima and Kazuhiko Yanai and Minoru Monma and Tatsuo Ido",

year = "1985",

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T2 - A new myocardial imaging tracer for positron emission tomography

AU - Ishiwata, Kiichi

AU - Miura, Yuka

AU - Takahashi, Toshihiro

AU - Kawashima, Koichiro

AU - Yanai, Kazuhiko

AU - Monma, Minoru

AU - Ido, Tatsuo

PY - 1985/10

Y1 - 1985/10

N2 - Coenzyme Q10 (CoQ10) is a co-factor of the mitochondrial electron-transfer system. 11C-Labeled CoQ10 was synthesized and its biodistribution in rats was examined comparing two kinds of preparation methods using different emulsifiers as a basic study for application of positron emission tomography. 11C-CoQ10 emulsified in saline with polyoxyethylene hydrogenated caster oil was present in the highest concentration in the blood at 30 min. On the other hand, the 11C-CoQ10 emulsified with phospholipids was rapidly cleared from the blood. The liver and spleen uptakes were high probably due to endocytosis, reflecting the characteristics of liposomes. The myocardial uptake was also high just after administration, and the heart-to-blood concentration ratio was over 10 after 5 min. These results suggest that 11C-CoQ10 prepared with liposomes may be a myocardial imaging tracer.

AB - Coenzyme Q10 (CoQ10) is a co-factor of the mitochondrial electron-transfer system. 11C-Labeled CoQ10 was synthesized and its biodistribution in rats was examined comparing two kinds of preparation methods using different emulsifiers as a basic study for application of positron emission tomography. 11C-CoQ10 emulsified in saline with polyoxyethylene hydrogenated caster oil was present in the highest concentration in the blood at 30 min. On the other hand, the 11C-CoQ10 emulsified with phospholipids was rapidly cleared from the blood. The liver and spleen uptakes were high probably due to endocytosis, reflecting the characteristics of liposomes. The myocardial uptake was also high just after administration, and the heart-to-blood concentration ratio was over 10 after 5 min. These results suggest that 11C-CoQ10 prepared with liposomes may be a myocardial imaging tracer.

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KW - Myocardial imaging

KW - Positron

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