Sugar-sensitive polyelectrolyte microcapsules containing insulin

Katsuhiko Sato; Daisuke Kodama; Yoshihiro Endo; Kentaro Yoshida; Jun Ichi Anzai

doi:10.1295/koron.67.544

Sugar-sensitive polyelectrolyte microcapsules containing insulin

Katsuhiko Sato, Daisuke Kodama, Yoshihiro Endo, Kentaro Yoshida, Jun Ichi Anzai

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Sugar-sensitive microcapsules containing insulin were prepared by a layer-by-layer (LbL) deposition of alginic acid (AGA) and phenylboronic acid-modified poly (allylamine) (PBA-PAH) on the surface of a calcium carbonate (CaCO₃) microparticle in which insulin had been embedded, followed by dissolution of the CaCO₃ core. The microcapsules thus prepared were stable at pH 7.0-9.0. In the presence of 10-100 mM fructose or glucose, the release of insulin was significantly enhanced depending on solution pH and sugar concentration. The sugar-triggered release of insulin was explained on the basis of decomposition of the microcapsules, which in turn was caused by competitive binding of added sugar to the phenylboronic acid moieties in the LbL film.

Original language	English
Pages (from-to)	544-548
Number of pages	5
Journal	KOBUNSHI RONBUNSHU
Volume	67
Issue number	9
DOIs	https://doi.org/10.1295/koron.67.544
Publication status	Published - 2010 Sep

Keywords

Alginic acid
Glucose
Insulin release
Layer-by-Layer film
Phenylboronic acid
Polyelectrolyte microcapsule

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Materials Science (miscellaneous)
Environmental Science(all)
Polymers and Plastics

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abstract = "Sugar-sensitive microcapsules containing insulin were prepared by a layer-by-layer (LbL) deposition of alginic acid (AGA) and phenylboronic acid-modified poly (allylamine) (PBA-PAH) on the surface of a calcium carbonate (CaCO3) microparticle in which insulin had been embedded, followed by dissolution of the CaCO3 core. The microcapsules thus prepared were stable at pH 7.0-9.0. In the presence of 10-100 mM fructose or glucose, the release of insulin was significantly enhanced depending on solution pH and sugar concentration. The sugar-triggered release of insulin was explained on the basis of decomposition of the microcapsules, which in turn was caused by competitive binding of added sugar to the phenylboronic acid moieties in the LbL film.",

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author = "Katsuhiko Sato and Daisuke Kodama and Yoshihiro Endo and Kentaro Yoshida and Anzai, {Jun Ichi}",

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AU - Sato, Katsuhiko

AU - Kodama, Daisuke

AU - Endo, Yoshihiro

AU - Yoshida, Kentaro

AU - Anzai, Jun Ichi

PY - 2010/9

Y1 - 2010/9

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KW - Polyelectrolyte microcapsule

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