Sugar-sensitive polyelectrolyte microcapsules containing insulin

Katsuhiko Sato, Daisuke Kodama, Yoshihiro Endo, Kentaro Yoshida, Jun Ichi Anzai

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Sugar-sensitive microcapsules containing insulin were prepared by a layer-by-layer (LbL) deposition of alginic acid (AGA) and phenylboronic acid-modified poly (allylamine) (PBA-PAH) on the surface of a calcium carbonate (CaCO3) microparticle in which insulin had been embedded, followed by dissolution of the CaCO3 core. The microcapsules thus prepared were stable at pH 7.0-9.0. In the presence of 10-100 mM fructose or glucose, the release of insulin was significantly enhanced depending on solution pH and sugar concentration. The sugar-triggered release of insulin was explained on the basis of decomposition of the microcapsules, which in turn was caused by competitive binding of added sugar to the phenylboronic acid moieties in the LbL film.

Original languageEnglish
Pages (from-to)544-548
Number of pages5
JournalKOBUNSHI RONBUNSHU
Volume67
Issue number9
DOIs
Publication statusPublished - 2010 Sep

Keywords

  • Alginic acid
  • Glucose
  • Insulin release
  • Layer-by-Layer film
  • Phenylboronic acid
  • Polyelectrolyte microcapsule

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics

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