Sugar-induced disintegration of layer-by-layer assemblies composed of concanavalin A and glycogen

Katsuhiko Sato, Yoko Imoto, Jun Sugama, Shunsuke Seki, Hiroyuki Inoue, Tsuyoshi Odagiri, Tomonori Hoshi, Junichi Anzai

Research output: Contribution to journalArticlepeer-review

129 Citations (Scopus)


The glucose-sensitive multilayer films composed of concanavalin A (Con A)-dextran were studied for developing optical glucose sensors. The multilayer films were prepared on the surface of a quartz slide, which was treated in diclorodimethylsilane overnoght at room temperature. It was reported that the Con A-glycogen multilayer films were sensitive to sugars and can be fully disintegrated in the presence of D-glucose, D-mannose, and derivatives. The sugar-induced disintegration of Con A-glycogen films was evaluated by measuring absorption spectra of the films. The stability of the Con A-glycogen multilayer films, in the sugar-free buffer solutions at pH 6, 7, and 8, was also studied.

Original languageEnglish
Pages (from-to)797-799
Number of pages3
Issue number2
Publication statusPublished - 2005 Jan 18
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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