[Successful treatment using recombinant thrombomodulin for disseminated intravascular coagulation associated with recurrent prosthetic valve endocarditis].

Shinya Masuda, Osamu Adachi, Koki Ito, Satoshi Matsuo, Yukihiro Hayatsu, Yusuke Suzuki, Takeshi Saito, Masatoshi Akiyama, Kiichiro Kumagai, Naotaka Motoyoshi, Shunsuke Kawamoto, Yoshikatsu Saiki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Prosthetic valve endocarditis(PVE)occasionally evokes sepsis and disseminated intravascular coagulation(DIC). A 46-year-old man developed relapsing active PVE with an annular abscess and suffered from exacerbating sepsis and DIC. Despite the administration of antibiotics, his DIC score increased. Anti-DIC treatment with recombinant thrombomodulin (rTM) was initiated, and his DIC was remarkably resolved. Accordingly, the abscess cavity was closed by using a homograft anterior mitral leaflet, and the aortic root was replaced with the homograft. He is doing well without an evidence of recurrent endocarditis 18 months after the operation. rTM is a new and promising drug for the treatment of DIC with infective endocarditis.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalUnknown Journal
Volume66
Issue number2
Publication statusPublished - 2013 Feb

ASJC Scopus subject areas

  • Medicine(all)

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