Successful treatment of unresectable recurrent cutaneous squamous cell carcinoma of the scalp with meningeal invasion with nivolumab monotherapy

Taku Fujimura, Yumi Kambayashi, Hisayuki Tono, Chinbing Lyu, Kentaro Ohuchi, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journalArticle

Abstract

Although the number of cutaneous squamous cell carcinoma (cSCC) cases is increasing, the effectiveness of systemic therapy for the treatment of advanced cSCC is limited. Since cSCC possesses a high tumor mutation burden (TMB) compared to other cancer species, and since high TMB correlated with increased neoantigens and the efficacy of anti-PD1 antibodies (Abs) in various cancers, cSCC could be a target for anti-PD1 Abs monotherapy. In this report, we describe a case of unresectable recurrent cSCC of the scalp with meningeal invasion, but highly expressed programmed death-ligand 1 (PD-L1), treated with nivolumab monotherapy.

Original languageEnglish
Article numbere13672
JournalDermatologic Therapy
Volume33
Issue number4
DOIs
Publication statusPublished - 2020 Jul 1

Keywords

  • PD-1
  • PD-L1
  • cutaneous SCC
  • immunotherapy
  • nivolumab

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Successful treatment of unresectable recurrent cutaneous squamous cell carcinoma of the scalp with meningeal invasion with nivolumab monotherapy'. Together they form a unique fingerprint.

  • Cite this