Successful treatment of unresectable recurrent cutaneous squamous cell carcinoma of the scalp with meningeal invasion with nivolumab monotherapy

Taku Fujimura; Yumi Kambayashi; Hisayuki Tono; Chinbing Lyu; Kentaro Ohuchi; Akira Hashimoto; Setsuya Aiba

doi:10.1111/dth.13672

Successful treatment of unresectable recurrent cutaneous squamous cell carcinoma of the scalp with meningeal invasion with nivolumab monotherapy

Taku Fujimura, Yumi Kambayashi, Hisayuki Tono, Chinbing Lyu, Kentaro Ohuchi, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journal › Article

Abstract

Although the number of cutaneous squamous cell carcinoma (cSCC) cases is increasing, the effectiveness of systemic therapy for the treatment of advanced cSCC is limited. Since cSCC possesses a high tumor mutation burden (TMB) compared to other cancer species, and since high TMB correlated with increased neoantigens and the efficacy of anti-PD1 antibodies (Abs) in various cancers, cSCC could be a target for anti-PD1 Abs monotherapy. In this report, we describe a case of unresectable recurrent cSCC of the scalp with meningeal invasion, but highly expressed programmed death-ligand 1 (PD-L1), treated with nivolumab monotherapy.

Original language	English
Article number	e13672
Journal	Dermatologic Therapy
Volume	33
Issue number	4
DOIs	https://doi.org/10.1111/dth.13672
Publication status	Published - 2020 Jul 1

Keywords

PD-1
PD-L1
cutaneous SCC
immunotherapy
nivolumab

ASJC Scopus subject areas

Dermatology

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Fujimura, T., Kambayashi, Y., Tono, H., Lyu, C., Ohuchi, K., Hashimoto, A., & Aiba, S. (2020). Successful treatment of unresectable recurrent cutaneous squamous cell carcinoma of the scalp with meningeal invasion with nivolumab monotherapy. Dermatologic Therapy, 33(4), [e13672]. https://doi.org/10.1111/dth.13672

Successful treatment of unresectable recurrent cutaneous squamous cell carcinoma of the scalp with meningeal invasion with nivolumab monotherapy. / Fujimura, Taku ; Kambayashi, Yumi; Tono, Hisayuki; Lyu, Chinbing; Ohuchi, Kentaro; Hashimoto, Akira ; Aiba, Setsuya.

In: Dermatologic Therapy, Vol. 33, No. 4, e13672, 01.07.2020.

Research output: Contribution to journal › Article

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