Successful treatment of plasmacytosis circumorificialis with topical tacrolimus: Two case reports and an immunohistochemical study

Taku Fujimura, Sadanori Furudate, Masaya Ishibashi, Yumi Kambayashi, Gen Ichi Tojo, Chihiro Wakusawa, Hiroshi Mayama, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163 + proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalCase Reports in Dermatology
Volume5
Issue number1
DOIs
Publication statusPublished - 2013 Jan
Externally publishedYes

Keywords

  • CD163 macrophages
  • IL-17
  • Plasmacytosis circumorificialis
  • Proinflammatory cytokine
  • Tacrolimus

ASJC Scopus subject areas

  • Dermatology

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