Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod

Taku Fujimura, Yumi Kambayashi, Yota Sato, Kayo Tanita, Sadanori Furudate, Akira Tsukada, Hisayuki Tono, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Simultaneous or sequential, planned administration of ipilimumab could significantly enhance the antitumor effects of nivolumab in advanced melanoma patients. On the other hand, the efficacy of ipilimumab for nivolumab-resistant advanced melanoma is extremely poor. Therefore, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma has been widely investigated. In this report, we describe a case of multiple in-transit melanomas developing in a nivolumab-resistant patient successfully treated with ipilimumab in combination with imiquimod. Our present case suggested a possible therapy for nivolumab-resistant multiple in-transit melanomas using ipilimumab in combination with topical imiquimod.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCase Reports in Oncology
Volume11
Issue number1
DOIs
Publication statusPublished - 2018 Jan 19

Keywords

  • Imiquimod
  • Ipilimumab
  • Nivolumab-resistant melanoma

ASJC Scopus subject areas

  • Oncology

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