Successful treatment of granuloma faciale with topical tacrolimus: A case report and immunohistochemical study

Gen Ichi Tojo, Taku Fujimura, Yumi Kambayashi, Katsuko Kikuchi, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3 +, CD4 +, CD8 +, CD68 + and CD163 + cells. Interestingly, these cells contained granulysin + T cells and lacked Foxp3 high+ regulatory T cells. In addition, the macrophages were mainly CD163 +, which suggested that the alternatively activated macrophage is one of the main components of GF. In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalCase Reports in Dermatology
Volume4
Issue number2
DOIs
Publication statusPublished - 2012 May
Externally publishedYes

Keywords

  • Granuloma faciale
  • Proinflammatory cytokine
  • Tacrolimus

ASJC Scopus subject areas

  • Dermatology

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