TY - JOUR
T1 - Successful treatment of granuloma faciale with topical tacrolimus
T2 - A case report and immunohistochemical study
AU - Tojo, Gen Ichi
AU - Fujimura, Taku
AU - Kambayashi, Yumi
AU - Kikuchi, Katsuko
AU - Aiba, Setsuya
PY - 2012/5
Y1 - 2012/5
N2 - We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3 +, CD4 +, CD8 +, CD68 + and CD163 + cells. Interestingly, these cells contained granulysin + T cells and lacked Foxp3 high+ regulatory T cells. In addition, the macrophages were mainly CD163 +, which suggested that the alternatively activated macrophage is one of the main components of GF. In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus.
AB - We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3 +, CD4 +, CD8 +, CD68 + and CD163 + cells. Interestingly, these cells contained granulysin + T cells and lacked Foxp3 high+ regulatory T cells. In addition, the macrophages were mainly CD163 +, which suggested that the alternatively activated macrophage is one of the main components of GF. In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus.
KW - Granuloma faciale
KW - Proinflammatory cytokine
KW - Tacrolimus
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U2 - 10.1159/000341196
DO - 10.1159/000341196
M3 - Article
C2 - 22807901
AN - SCOPUS:84866714486
VL - 4
SP - 158
EP - 162
JO - Case Reports in Dermatology
JF - Case Reports in Dermatology
SN - 1662-6567
IS - 2
ER -