Abstract
We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3 +, CD4 +, CD8 +, CD68 + and CD163 + cells. Interestingly, these cells contained granulysin + T cells and lacked Foxp3 high+ regulatory T cells. In addition, the macrophages were mainly CD163 +, which suggested that the alternatively activated macrophage is one of the main components of GF. In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus.
Original language | English |
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Pages (from-to) | 158-162 |
Number of pages | 5 |
Journal | Case Reports in Dermatology |
Volume | 4 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2012 May |
Keywords
- Granuloma faciale
- Proinflammatory cytokine
- Tacrolimus
ASJC Scopus subject areas
- Dermatology