Successful treatment of granuloma faciale with topical tacrolimus: A case report and immunohistochemical study

Gen Ichi Tojo; Taku Fujimura; Yumi Kambayashi; Katsuko Kikuchi; Setsuya Aiba

doi:10.1159/000341196

Successful treatment of granuloma faciale with topical tacrolimus: A case report and immunohistochemical study

Gen Ichi Tojo, Taku Fujimura, Yumi Kambayashi, Katsuko Kikuchi, Setsuya Aiba

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3 ⁺, CD4 ⁺, CD8 ⁺, CD68 ⁺ and CD163 ⁺ cells. Interestingly, these cells contained granulysin ⁺ T cells and lacked Foxp3 ^high+ regulatory T cells. In addition, the macrophages were mainly CD163 ⁺, which suggested that the alternatively activated macrophage is one of the main components of GF. In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus.

Original language	English
Pages (from-to)	158-162
Number of pages	5
Journal	Case Reports in Dermatology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1159/000341196
Publication status	Published - 2012 May

Keywords

Granuloma faciale
Proinflammatory cytokine
Tacrolimus

ASJC Scopus subject areas

Dermatology

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10.1159/000341196

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abstract = "We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3 +, CD4 +, CD8 +, CD68 + and CD163 + cells. Interestingly, these cells contained granulysin + T cells and lacked Foxp3 high+ regulatory T cells. In addition, the macrophages were mainly CD163 +, which suggested that the alternatively activated macrophage is one of the main components of GF. In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus.",

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AU - Tojo, Gen Ichi

AU - Fujimura, Taku

AU - Kambayashi, Yumi

AU - Kikuchi, Katsuko

AU - Aiba, Setsuya

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AB - We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3 +, CD4 +, CD8 +, CD68 + and CD163 + cells. Interestingly, these cells contained granulysin + T cells and lacked Foxp3 high+ regulatory T cells. In addition, the macrophages were mainly CD163 +, which suggested that the alternatively activated macrophage is one of the main components of GF. In summary, the present data shed light on the granuloma-composing cells and possible mechanisms in the treatment of GF with topical tacrolimus.

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