Successful treatment of a 2-year-old girl with intractable myasthenia gravis using tacrolimus

Yosuke Kakisaka, Kazuhiro Haginoya, Hiroyuki Yokoyama, Mamiko Ishitobi, Keisuke Wakusawa, Ikuko Sato, Noriko Togashi, Taro Kitamura, Naomi Fukuyo, Yasushi Yoshihara, Kazuie Iinuma

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


We used tacrolimus to successfully treat a patient with childhood-onset oropharyngeal myasthenia gravis (MG). A girl (2 years, 5 months old) with oropharyngeal MG responded partially to treatment including pyridostigmine bromide, intravenous immunoglobulin, and prednisolone (2 mg/kg/day) for 7 weeks, but this resulted in worsening of her eye symptoms. By contrast, tacrolimus at 2 mg/day resulted in complete remission of the MG, which made it possible to reduce the dose of prednisolone. This is a rare report of the use of tacrolimus as an effective treatment for patients with intractable childhood-onset MG.

Original languageEnglish
Pages (from-to)534-536
Number of pages3
JournalBrain and Development
Issue number8
Publication statusPublished - 2006 Sep


  • Childhood
  • Immunosuppressant
  • Myasthenia gravis
  • Tacrolimus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology


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