Successful cord blood stem cell transplantation for primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma complicated with cerebral infiltration

Satoshi Ichikawa, Noriko Fukuhara, Shunsuke Hatta, Masahito Himuro, Hiroki Katsushima, Kentaro Nasu, Koya Ono, Kyoko Inokura, Masahiro Kobayashi, Yasushi Onishi, Hiroshi Fujii, Kenichi Ishizawa, Ryo Ichinohasama, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A 16-year-old boy, who had been initially examined for bilateral blepharedema and slight eruption, presented with rapidly deteriorating symptoms in associating with headache and consciousness disturbance. He was diagnosed to have primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAE-CTL) by a biopsy of the skin and brain. After whole-brain radiation and some courses of chemotherapy, cord blood transplantation was performed with myeloablative conditioning. After transplantation, the cerebral dysfunction gradually improved. Disease remission was confirmed by the disappearance of any abnormal findings on electroencephalogram and magnetic resonance imaging. PCAE-CTL is reported to be an extremely aggressive disease with a poor prognosis, but the timely performance of cord blood transplantation is considered to be a promising treatment strategy.

Original languageEnglish
Pages (from-to)2051-2055
Number of pages5
JournalInternal Medicine
Volume57
Issue number14
DOIs
Publication statusPublished - 2018

Keywords

  • Cerebral infiltration
  • Cord blood transplantation
  • Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma

ASJC Scopus subject areas

  • Internal Medicine

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