Substrates for growth cone guidance in brain: Guidance cues for neural connections

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Abstract

Neurons extend their neurites to a target during neural development in the brain. During this process, guiding substrates play an important role in guiding the growth cones, the tip of the axons/neurites, precisely to their specific targets. This guidance result in the establishment of a neural circuit in the brain. In this review, I will describe the substrates which may guide the growth cone of the axons/neurites to their targets thus forming synaptic neural connections, and also discuss the mechanisms of this neuronal guidance.

Original languageEnglish
Pages (from-to)69-88
Number of pages20
JournalMaterials Science Forum
Volume250
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Axon
  • CAM
  • Chemoattractant
  • Growth Cone
  • Guidance
  • Guiding Substrates
  • Laminin
  • NGF
  • Neurite
  • Patterned Substrates

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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