Substrate specificity of urate transporter in rat renal brush border membranes

Takashi Dan, Hiroshi Koga

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To further demonstrate the substrate specificity of urate-anion exchanger in rat renal brush border membrane vesicles, the hydroxyl ion gradient-dependent [2-14C] urate uptake was studied by a rapid filtration technique. The [2-14C] urate uptake was more sensitive to unlabeled urate than to unlabeled xanthine and hypoxanthine. In addition, urate derivatives which are methylated at the positions 3 and 9 hardly inhibited the urate uptake. Because of the substrate specificity, the urate-anion exchanger in brush border membranes appears to selectively use urate as the endogenous substrate.

Original languageEnglish
Pages (from-to)1963-1968
Number of pages6
JournalLife Sciences
Volume48
Issue number20
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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