Substitution of asparagine324 with aspartic acid in the fc portion of mouse antibodies reduces their capacity for clq binding

Masato Nose; Thomas Leanderson

doi:10.1002/eji.1830191133

Substitution of asparagine³²⁴ with aspartic acid in the fc portion of mouse antibodies reduces their capacity for clq binding

Masato Nose, Thomas Leanderson

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The sequence of the heavy chain C region of mouse mutant IgG_2a antibodies with reduced capacity for Clq binding but with retained ability for Fc receptor‐mediated functions was determined by cDNA cloning and by mRNA sequencing. The specific mutation was found to be the substitution of asparagine³²⁴ with aspartic acid. Asparagine³²⁴ represents a new residue relating to the Clq‐binding sites previously described.

Original language	English
Pages (from-to)	2179-2181
Number of pages	3
Journal	European Journal of Immunology
Volume	19
Issue number	11
DOIs	https://doi.org/10.1002/eji.1830191133
Publication status	Published - 1989 Nov

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1002/eji.1830191133

Cite this

@article{0abb2145db1b40bdae54ce77afd14b83,

title = "Substitution of asparagine324 with aspartic acid in the fc portion of mouse antibodies reduces their capacity for clq binding",

abstract = "The sequence of the heavy chain C region of mouse mutant IgG2a antibodies with reduced capacity for Clq binding but with retained ability for Fc receptor‐mediated functions was determined by cDNA cloning and by mRNA sequencing. The specific mutation was found to be the substitution of asparagine324 with aspartic acid. Asparagine324 represents a new residue relating to the Clq‐binding sites previously described.",

author = "Masato Nose and Thomas Leanderson",

year = "1989",

month = nov,

doi = "10.1002/eji.1830191133",

language = "English",

volume = "19",

pages = "2179--2181",

journal = "European Journal of Immunology",

issn = "0014-2980",

publisher = "Wiley-VCH Verlag",

number = "11",

}

TY - JOUR

T1 - Substitution of asparagine324 with aspartic acid in the fc portion of mouse antibodies reduces their capacity for clq binding

AU - Nose, Masato

AU - Leanderson, Thomas

PY - 1989/11

Y1 - 1989/11

N2 - The sequence of the heavy chain C region of mouse mutant IgG2a antibodies with reduced capacity for Clq binding but with retained ability for Fc receptor‐mediated functions was determined by cDNA cloning and by mRNA sequencing. The specific mutation was found to be the substitution of asparagine324 with aspartic acid. Asparagine324 represents a new residue relating to the Clq‐binding sites previously described.

AB - The sequence of the heavy chain C region of mouse mutant IgG2a antibodies with reduced capacity for Clq binding but with retained ability for Fc receptor‐mediated functions was determined by cDNA cloning and by mRNA sequencing. The specific mutation was found to be the substitution of asparagine324 with aspartic acid. Asparagine324 represents a new residue relating to the Clq‐binding sites previously described.

UR - http://www.scopus.com/inward/record.url?scp=0024854278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024854278&partnerID=8YFLogxK

U2 - 10.1002/eji.1830191133

DO - 10.1002/eji.1830191133

M3 - Article

C2 - 2599005

AN - SCOPUS:0024854278

VL - 19

SP - 2179

EP - 2181

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 11

ER -

Substitution of asparagine³²⁴ with aspartic acid in the fc portion of mouse antibodies reduces their capacity for clq binding

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this