The sequence of the heavy chain C region of mouse mutant IgG2a antibodies with reduced capacity for Clq binding but with retained ability for Fc receptor‐mediated functions was determined by cDNA cloning and by mRNA sequencing. The specific mutation was found to be the substitution of asparagine324 with aspartic acid. Asparagine324 represents a new residue relating to the Clq‐binding sites previously described.
ASJC Scopus subject areas
- Immunology and Allergy