Substituent effect on the yield of unpaired electrons in DNA bases studied by electron paramagnetic resonance

Toshitaka Oka, Akinari Yokoya, Kentaro Fujii, Yasushi Kino, Tsutomu Sekine

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The physicochemical processes underlying the radiation sensitization of DNA by the K-shell photoabsorption of nitrogen and oxygen atoms are unclear. Accordingly, we evaluated electron paramagnetic resonance spectra of thin films of pyrimidine bases. By altering the substituents of the pyrimidine ring, we found a substituent effect on the yield of unpaired electrons induced by photoabsorption. The yield of the unpaired electrons of the DNA-base containing amino groups increased by the donation of electrons, and the yield of halogenated DNA-bases decreased by the withdrawal of electrons. These different physicochemical processes might affect DNA bases, leading to differences in DNA modification.

Original languageEnglish
Article number243701
JournalApplied Physics Letters
Volume113
Issue number24
DOIs
Publication statusPublished - 2018 Dec 10

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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