Subnormal peripheral blood leukocyte counts are related to the lowest prevalence and incidence of metabolic syndrome: Tianjin chronic low-grade systemic inflammation and health cohort study

Shaomei Sun, Hongmei Wu, Qing Zhang, Chongjin Wang, Yinting Guo, Huanmin Du, Li Liu, Qiyu Jia, Xing Wang, Kun Song, Kaijun Niu

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28 Citations (Scopus)

Abstract

Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n=46,179) and a prospective assessment (n=13,061) were performed. Participants without a history of MS were followed up for 5 years. Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up. Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS. The subnormal leukocyte counts group (1,100&x2013;3, 900&x2009;cells/mm3) had the lowest prevalence and incidence of MS. The odds ratio and hazard ratio (95&x25; confidence interval) of the highest leukocyte counts were 1.98 (1.57&x2013;2.49) and 1.50 (1.22&x2013;1.84) (both P for trend &x3C;0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders. This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS. The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts.

Original languageEnglish
Article number412386
JournalMediators of Inflammation
Volume2014
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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