Submucosal gland cells in human lower airways produce MUC5AC protein

Daisuke Inoue, Hiroshi Kubo, Mika Watanabe, Takahiko Sasaki, Hiroyasu Yasuda, Muneo Numasaki, Hidetada Sasaki, Mutsuo Yamaya

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background and objective: It is now considered that the major component of mucus, MUC5AC, is mainly produced by goblet cells but not submucosal glands, and the role of the submucosal glands in the production of MUC5AC is unclear. The aim of this study was to clarify whether human submucosal glands produce MUC5AC. Methods: Immunohistochemical analysis with MUC5AC antibody of lower airways resected from six lung cancer patients and three patients with acute myocardial infarction was performed. Results: The submucosal glands contained both MUC5AC-positive cells and non-positive cells. Conclusions: These data suggest that MUC5AC protein is produced in both goblet cells and in airway submucosal glands.

Original languageEnglish
Pages (from-to)285-287
Number of pages3
Issue number2
Publication statusPublished - 2008 Mar 1


  • Airway mucus
  • MUC5AC protein
  • Submucosal gland

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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