Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica

Tetsuya Akaishi, Kimihiko Kaneko, Noriko Himori, Takayuki Takeshita, Toshiyuki Takahashi, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, macular GCC and circum-papillary RNFL in the unaffected eyes were both atrophied in MS-ON and AQP4-ON, but were not atrophied in the others. Titers of anti-AQP4-Ab was suggested to be associated with such latent neurodegenerative process in AQP4-ON. Long-term follow up of OCT is recommended even in the unaffected side in MS-ON and AQP4-ON.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalJournal of Neuroimmunology
Volume313
DOIs
Publication statusPublished - 2017 Dec 15

Keywords

  • Multiple sclerosis
  • Myelin oligodendrocyte glycoprotein
  • Neuromyelitis optica
  • Optic coherence tomography
  • Unaffected side

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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