Subcellular organelle analysis applying confocal laser scanning microscopy to the steroid-producing epithelial ovarian tumor: A technical note

Masanori Yasuda, Johbu Itoh, Toshinari Muramatsu, Takao Shinozuka, Hironobu Sasano, Yutaka Tsutsumi, R. Yoshiyuki Osamura

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

An epithelial ovarian tumor with steroid production was examined in a 70-year-old postmenopausal female. The stromal cells of this tumor were rather dense and occasionally characterized by luteinization or hyperthecosis, which has been associated with steroidogenesis. Subcellular visualization using confocal laser scanning microscopy (CLSM) successfully led to the identification of 3β-hydroxysteroid dehydrogenase (HSD) in both mitochondria-like small particles and endoplasmic reticulum-like linear profiles, and P450-aromatase also in endoplasmic reticulum-like linear profiles, on the three-dimensional images.

Original languageEnglish
Pages (from-to)336-338
Number of pages3
JournalPathology international
Volume47
Issue number5
DOIs
Publication statusPublished - 1997

Keywords

  • confocal laser scanning microscopy
  • epithelial ovarian tumor
  • steroidogenic stroma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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