Sub-piconewton force fluctuations of actomyosin in vitro

Akihiko Ishijima, Takashi Doi, Katsuhiko Sakurada, Toshio Yanagida

Research output: Contribution to journalArticlepeer-review

214 Citations (Scopus)


A new system has been developed for measuring the forces produced by a small number (<5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations of force caused by individual molecular interactions. From analysis of these force fluctuations, the coupling between the enzymatic ATPase activity of actomyosin and the resulting mechanical impulses can be elucidated.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
Issue number6333
Publication statusPublished - 1991

ASJC Scopus subject areas

  • General


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