Study of the familiar form of vascular dementia (CADASIL)

Keikichi Takahashi, Kaichi Yoshizaki

Research output: Contribution to journalShort surveypeer-review


CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited disease characterized by recurrent subcortical ischemic strokes leading to pseudobulbar palsy, migraine attacks with aura, psychiatric disturbances and vascular dementia. The disease is caused by mutations in the Notch3 receptor. In the present study, we investigated the mechanisms underlying the pathological alterations in CADASIL. We found no difference in the receptor trafficking, processing, or specificity for ligand binding or signal transduction between WT and mutant Notch3 receptors. These results suggest that pathological alterations in CADASIL are not caused by defects in Notch3 processing or signaling.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalJapanese Journal of Neuropsychopharmacology
Issue number3
Publication statusPublished - 2007 Jun 1


  • Notch3
  • Signal transduction
  • Smooth muscle cell
  • Vascular dementia

ASJC Scopus subject areas

  • Clinical Psychology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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