Study of the binding mode of a chromophoric host zinc protoporphyrin with histamine

Ai Jun Tong, Chun Yuan Tong, Qing Yi Yang, Yuichi Kato, Seiichi Nishizawa, Norio Teramae

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Molecular recognition of histamine by Zn(II)-protoporphyrin (ZnPP) in water was investigated by using UV-Vis titration. An NOE mode of 1 H NMR was used to study the host-guest binding in DMSO-d 6 solution. Changes of proton chemical shifts for both ZnPP and histamine before and after complexing and a computer aided structure simulation confirmed our suggested binding mode that two hydrogen bonds between amino group of histamine and the two carboxylic acid groups of ZnPP as well as coordination of zinc to imidazole contribute to the binding.

Original languageEnglish
Pages (from-to)905-910
Number of pages6
JournalActa Chimica Sinica
Volume62
Issue number9
Publication statusPublished - 2004 Dec 1

Keywords

  • H NMR
  • Histamine
  • Molecular orbit model
  • UV-Vis
  • Zn(II)-protoporphyrin

ASJC Scopus subject areas

  • Chemistry(all)

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