Study of leaving groups for the preparation of [ω-18F]fluorofatty acids via nucleophilic fluorination and its application to the synthesis of 17-[18F]fluoro-3-methylheptadecanoic acid

Toshihiro Takahashi, Tatsuo Ido, Ren Iwata

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    The effect of leaving groups on the introduction of [18F]fluorine into fatty acids via nucleophilic fluorination has been systematically studied. It has been proved that tosylate and bromide are the most reactive among such leaving groups as chloride, bromide, iodide, mesylate, tosylate and triflate. This result has been applied to the synthesis of 17-[18F]fluoro-3-methylheptadecanoic acid used in routine medical studies. Using methyl 17-bromo-3-methylheptadecanoate, the 18F-labeled 3-methyl-branched fatty acid has been prepared in a radiochemical yield of 36-58% (based on 18F-) with radiochemical purities of > 97%.

    Original languageEnglish
    Pages (from-to)801-809
    Number of pages9
    JournalInternational Journal of Radiation Applications and Instrumentation. Part
    Volume42
    Issue number9
    DOIs
    Publication statusPublished - 1991

    ASJC Scopus subject areas

    • Radiation
    • Engineering(all)

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