Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse

Yoshiko Takano, Hiroshi Ohguro, Mari Dezawa, Hiroto Ishikawa, Hitoshi Yamazaki, Ikuyo Ohguro, Kazuhisa Mamiya, Tomomi Metoki, Futoshi Ishikawa, Mitsuru Nakazawa

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

In the present study, we studied drug effects of Ca2+ antagonists on the retinal degeneration of rd mouse to evaluate their efficacy. Several kinds of Ca2+ antagonists, diltiazem, nicardipine, nilvadipine or nifedipine were administrated intraperitoneally and thereafter retinal morphology and functions were analyzed. In addition, we performed DNA microarray analysis both in nilvadipine treated and control retinas to understand their drug effects at molecular levels. We found that nilvadipine caused significant preservation of retinal thickness in rd mouse during the initial stage of the retinal degeneration, and nicardipine showed also significant but lesser preservation than nilvadipine. However, we recognized no preservation effects of diltiazem and nifedipine. In the total 3774 genes, the expressions of 27 genes were altered upon administration of nilvadipine, including several genes related to the apoptotic pathway, neuro-survival factor, Ca2+ metabolisms, and other mechanisms. It is suggested that some types of Ca2+ channel blockers, such as nilvadipine and nicardipine, are able to preserve photoreceptor cells in rd mouse and can potentially be used to treat some RP patients.

Original languageEnglish
Pages (from-to)1015-1022
Number of pages8
JournalBiochemical and biophysical research communications
Volume313
Issue number4
DOIs
Publication statusPublished - 2004 Jan 23
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse'. Together they form a unique fingerprint.

Cite this