Study design of a phase ii clinical trial to assess the efficacy and safety of eperisone in japanese type 2 diabetes patients with risk and non-risk alleles of CDKAL1

Kourin Sakakida, Fan Yan Wei, Takafumi Senokuchi, Seiya Shimoda, Tatsuyuki Kakuma, Eiichi Araki, Kazuhito Tomizawa

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1- deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1. The primary endpoint is the change of hemoglobin A1c (HbA1c) levels. We also examined whether the efficacy of eperisone in T2D patients is associated with CDKAL1 activity.

Original languageEnglish
Pages (from-to)423-426
Number of pages4
JournalActa medica Okayama
Volume72
Issue number4
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Keywords

  • Diabetes
  • Glucose
  • Insulin secretion
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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