Studies toward the total synthesis of gymnocin A, a cytotoxic polyether: A highly convergent entry to the F-N ring fragment

Makoto Sasaki; Chihiro Tsukano; Kazuo Tachibana

doi:10.1021/ol025814u

Studies toward the total synthesis of gymnocin A, a cytotoxic polyether: A highly convergent entry to the F-N ring fragment

Makoto Sasaki, Chihiro Tsukano, Kazuo Tachibana

LIF - Molecular and Chemical Life Science

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Matrix presented An efficient and highly convergent synthesis of the FGHIJKLMN ring fragment of gymnocin A, a cyctotoxic polycyclic ether isolated from the notorious red-tide forming dinoflagellate Gymnodinium mikimotoi, has been achieved. The present synthesis relied on extensive use of the B-alkyl Suzuki-Miyaura coupling reaction.

Original language	English
Pages (from-to)	1747-1750
Number of pages	4
Journal	Organic letters
Volume	4
Issue number	10
DOIs	https://doi.org/10.1021/ol025814u
Publication status	Published - 2002 May 16

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol025814u

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abstract = "Matrix presented An efficient and highly convergent synthesis of the FGHIJKLMN ring fragment of gymnocin A, a cyctotoxic polycyclic ether isolated from the notorious red-tide forming dinoflagellate Gymnodinium mikimotoi, has been achieved. The present synthesis relied on extensive use of the B-alkyl Suzuki-Miyaura coupling reaction.",

author = "Makoto Sasaki and Chihiro Tsukano and Kazuo Tachibana",

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AU - Tsukano, Chihiro

AU - Tachibana, Kazuo

PY - 2002/5/16

Y1 - 2002/5/16

N2 - Matrix presented An efficient and highly convergent synthesis of the FGHIJKLMN ring fragment of gymnocin A, a cyctotoxic polycyclic ether isolated from the notorious red-tide forming dinoflagellate Gymnodinium mikimotoi, has been achieved. The present synthesis relied on extensive use of the B-alkyl Suzuki-Miyaura coupling reaction.

AB - Matrix presented An efficient and highly convergent synthesis of the FGHIJKLMN ring fragment of gymnocin A, a cyctotoxic polycyclic ether isolated from the notorious red-tide forming dinoflagellate Gymnodinium mikimotoi, has been achieved. The present synthesis relied on extensive use of the B-alkyl Suzuki-Miyaura coupling reaction.

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Studies toward the total synthesis of gymnocin A, a cytotoxic polyether: A highly convergent entry to the F-N ring fragment

Abstract

ASJC Scopus subject areas

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