Studies toward the total synthesis of gambieric acids: Stereocontrolled synthesis of a DEFG-ring model compound

Haruhiko Fuwa, Sayaka Noji, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    (Figure presented) A stereocontrolled convergent synthesis of a DEFG-ring model compound of gambieric acids, highly potent antifungal marine polycyclic ether natural products, has been achieved based on Suzuki- Miyaura coupling. Conformational analysis of the model compound revealed that the nine-membered F-ring exists exclusively as a single stable conformer, as opposed to that of ciguatoxins.

    Original languageEnglish
    Pages (from-to)5072-5082
    Number of pages11
    JournalJournal of Organic Chemistry
    Volume75
    Issue number15
    DOIs
    Publication statusPublished - 2010 Aug 6

    ASJC Scopus subject areas

    • Organic Chemistry

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